From Strep to Stroke: Medical Conditions That Can Cause Headaches
- Victoria Wermers, RN,MSN,FNP, PMHNP
- Oct 1, 2024
- 3 min read
Updated: Jul 6
Headaches Can Occur When You Have an Acute or Chronic Illness
Viral and bacterial infections are notorious for causing headaches: I frequently hear this complaint in the clinic. Illnesses like flu, COVID-19, sinusitis (face, forehead, between and behind eyes), and ear infections are the leading causes of acute headaches. Even strep and allergies can cause headaches.
These types of headaches may come and go or may be ongoing, lasting from hours to days until the illness finally dissipates. Want to know more? Read on about From Strep to Stroke: Medical Conditions That Can Cause Headaches.

What Physical Problems Can Cause Headaches?
Here are just a few medical causes of headaches:
Everyday illnesses like the flu, strep, and sinus infections
Fever
Dehydration
High Blood Pressure
Glaucoma
Anemia
Thyroid problems
Fibromyalgia
Medication side-effects
Head injuries
Immune compromise
Worst-case scenarios like a stroke, meningitis, or brain tumors: As clinicians, we were always reminded to refer patients with a severe, "worst headache I have ever had in my life" to the Emergency Room (that is a reminder to the reader as well).
Learn more about causes here.
Treating the Potential Cause
Treatment of the underlying illness is essential to getting rid of these headaches. In the meantime, you can try any of the following for relief.
Over-the-Counter Medicines
NSAIDS: Ibuprofen (common: Advil, Motrin), naproxen sodium (common: Aleve, Naprosyn), and the combination of caffeine, acetaminophen, and aspirin (common: Excedrin, Goody’s Powder). These are probably the best choices for headaches. Try to take NSAIDs with a little bit of food (as simple as a cracker) to avoid stomach irritation. If your headache is minor, take the lowest dose. If it is moderate, take the higher recommended dose.
Acetaminophen (common: Tylenol).
Take as directed over-the-counter if there are no contraindications.
Considered Natural Remedies
Prescriptive Treatment
Most providers will not prescribe medication for an acute headache when it is caused by an acute underlying illness. Over-the-counter medications will usually do the job. However, on rare occasions, they may be prescribed short-term: These include painkillers such as oxycodone or hydrocodone (combo opioids with Tylenol: Lortab, Percocet, and Vicodin) and Tramadol (i.e., Ultram). Because these are highly addictive, they are not the drug of choice for long-term pain.
From Strep to Stroke: Medical Conditions That Can Cause Headaches. Worst-case scenarios and Red Flags
You have a “thunderclap” headache – sudden severe onset - a "10 out of 10" - go to ER
Do not dismiss frequent or severe headaches, especially if accompanied by
vomiting (especially projectile - a forceful outward-directed emesis )
Double vision
Change in your level of consciousness or change in behavior
Recent head injury
It is new and lasting for a few days (especially in the absence of a known viral or bacterial infection)
Is excruciating
Has become chronic/ongoing and does not respond to medicines
If headaches are occurring frequently after exercise
Neck pain
New onset of headaches after 50 (according to the American Headache Society)
If you have more than one to two headaches a week or more than three to four per month
If you have less frequent headaches, but they are more severe and debilitating.
Your headaches start to feel different than your "usual" headaches.
Headaches accompanied by sudden weakness on one or both sides of the body



