
General Information
OTHER NAMES: Silybum marianum (active ingredient: silymarin). Not to be confused with regular thistle.
HISTORY: Estimates suggest that this has been used for two thousand years for liver ailments.
PROPERTIES: Antioxidant, anti-inflammatory
Considered Uses
Gastrointestinal: Hepatitis, cirrhosis (possibly caused by excessive alcohol and certain medications), fatty liver, indigestion (German Commission E), gallbladder, ulcerative colitis
Genitourinary: May help reduce symptoms in menopause (esp. hot flashes)
Skin: Possibly acne (little evidence)
Glucose: May help lower glucose levels
Cholesterol: Helps lower bad (LDL) cholesterol - especially in diabetics, increases good cholesterol
Cancer: Possibly anti-cancer
Other: Possibly instrumental in weight loss, may help decrease C-reactive protein (a measure of inflammation)
* * *
SIDE EFFECTS: Stomach problems, headache, rash, diarrhea
CAUTION/CONTRAINDICATIONS: Breast cancer, endometriosis, akkergirs to ragwees and related olants, uterine cancer and fibroids; diabetes medications (may make blood sugar too low), Interactions with many medications - especially anticoagulants, anticonvulsants, NSAIDS, Losartan and other CYP2C9 medications, potential cross-sensitivity for those with allergies to related plants (daisy, marigold, zinnias, etc. from the asteracae family)
FORMS: Capsules, tablets, extract
RECOMMENDED BRANDS
One of the biggest problems found in milk thistle products was pesticides. Some other products were found to have less than claimed levels of the active ingredient, silymarin. The following passed ConsumerLabs testing for quality:
Bronson® Milk Thistle (with dandelion root) capsules 111.1 mg (order through Amazon link)
Gaia Herbs® Milk Thistle capsules 750 mg (order through Amazon link here)
Jarrow Formulas® Milk Thistle capsules 150 mg (Order through Fullscript link here)
Life Extension® Advanced Milk Thistle softgels (link to order at Life Extensions)
I only recommend herbal and supplement brands that meet high standards for safety, effectiveness, and transparency. I research each product before sharing. Some links—like those to Amazon—are affiliate links, meaning I may earn a small commission if you buy through them, at no extra cost to you. It helps support this free site. Plus, these links often offer discounts, fast shipping, and helpful reviews.
DOSAGE: As directed
Reported doses – May NOT be supported by evidence (reported by various sources (WebMD, RxList, Epocrates, German Commission E, NIH publications). Read dosages and instructions carefully when available on the label.
20-300 mg by mouth 1-2 times daily
Type 2 diabetes 200-600 mg
*Disclaimer: The material above is for informational purposes only. This information is not intended to diagnose, treat or cure a condition. The uses listed above are tentative; some have or are undergoing research trials, but many are not FDA-approved. It is essential that you investigate these supplements further before deciding to use them. Check interactions and contraindications on sites like Drugs.com or WebMD. Do not attempt to treat a serious condition like liver, kidney problems, high blood pressure, heart, cancer, diabetes, or thyroid issues without discussing it with a healthcare provider first. If you are pregnant or nursing a baby, please do not use supplements without discussing it with your healthcare provider.